The Importance of Neutrophils in Osteoarthritis: Current Concepts and Therapeutic Perspectives

Osteoarthritis (OA) is the most common degenerative joint disease that causes chronic pain and disability. Different innate immune components, including macrophages, T cells, neutrophils, participate in OA pathophysiology. Neutrophils are abundant circulating leukocytes with multiple specialized functions contributing to adaptive functions. Although neutrophils produce proinflammatory cytokines chemokines, reactive oxygen species (ROS), matrix-degrading enzymes, neutrophil extracellular traps (NET) promote degradation as first recruit cells an inflamed joint, these also play important role repair by regulating response, releasing anti-inflammatory factors, activating certain protective genes. In this review, various aspects of biology, their inflammation its association OA, possible therapeutic approaches target for treatment described. Since a complex pathophysiology osteoarthritis, well repair, targeting likely pave way potential approach management OA. Future studies needed investigate use targeted therapies modulate function identify subpopulations associated osteoarthritis progression or response treatment.